BCR1 — Fusarium oxysporum Fo47

Summary

FoBCR1 (BCR1) on chromosome JH717899 of Fusarium oxysporum Fo47 encodes a C2H2-type zinc-finger protein with DNA-binding transcription factor activity, specifically binding cis-regulatory regions of RNA polymerase II promoters. The gene is associated with glucose-mediated downregulation of transcription, regulation of carbon utilization, and the oxidative branch of the pentose pathway. It is linked to numerous cellular processes including biofilm formation, chromatin modeling, and gene expression regulation, with the protein localizing to both cytoplasm and nucleus. Phenotypic associations connect FoBCR1 to sporulation, pseudohyphal growth, adhesion, cell cycle progression (G1, G2, and M phases), meiosis, nuclear fusion during mating, UV and ionizing radiation resistance, nitrogen source utilization, chitin deposition, autophagy, and protein secretion. Related genes in other species link the family to sugar content, germination rate, acid sensitivity, and oxidative stress response, as well as reduced virulence.