HST6 — Fusarium oxysporum Fo47

Summary

FoHST6 (FOZG_05960) of Fusarium oxysporum Fo47 encodes an ABC-type transporter with ATP hydrolase activity, belonging to the type 1 exporter family. The gene is associated with peptide pheromone export, oligopeptide export from mitochondria, conjugation with cellular fusion, pheromone response, and xenobiotic detoxification via transmembrane export across the plasma membrane. It is linked to response to antibiotic, membrane transport, and protein synthesis. The encoded protein localizes to the plasma membrane, fungal-type vacuole, mitochondrial inner membrane, cell tip, cell division site, and cortical dynamic polarity patch. Phenotypic associations include abnormal colony shape, decreased fermentative growth, delayed cell cycle progression, absent mating response, increased hyperosmotic stress resistance, and altered mitophagy and ribophagy. Studies of related genes in other species link the family to protein transport, nuclear import/export, and mitochondrial genome maintenance.