BRLA — Fusarium oxysporum Fo47

Summary

FoBRLA (FOZG_05133) on chromosome JH717898 of Fusarium oxysporum Fo47 encodes a transcription factor with sequence-specific DNA-binding activity. The gene is associated with mating behavior, parasexual conjugation, regulation of pseudohyphal and filamentous growth, sporocarp development, biofilm formation, phenotypic switching, secondary metabolite biosynthesis, pheromone response, immune evasion, and development of symbiont in host. It localizes to the nucleus, cytoplasm, membrane, chromatin, and Tec1p-Ste12p-Dig1p and Ste12p-Dig1p-Dig2p complexes. Phenotypic associations include abnormal biofilm formation, increased pheromone production, absent mating efficiency, abnormal carbon source utilization, decreased cell cycle progression, and increased polyploidy rate. Related genes in other species link the STE12 transcription factor family to sporogenesis, germination rate, oxidative stress response, and loss of pathogenicity.