GUS1 — Fusarium oxysporum Fo47

Summary

FOZG_16311 (GUS1, FoGUS1) in Fusarium oxysporum Fo47 on chromosome JH717910 encodes a glutamine-tRNA ligase and glutamate-tRNA ligase, possessing glutamine-tRNA ligase and glutamate-tRNA ligase activities, ATP binding, and sequence-specific mRNA binding. The protein localises to the cytosol, nucleus, mitochondria, stress granules, and the methionyl-glutamyl tRNA synthetase complex, and is associated with glutaminyl-tRNA and glutamyl-tRNA aminoacylation, as well as cytoplasmic translation. FoGUS1 is linked to numerous phenotypes including increased cell size, abnormal cell cycle progression in G1 phase, absent autophagy and pexophagy, decreased sporulation, filamentous growth, and protein secretion, increased innate thermotolerance and cold sensitivity, decreased hyperosmotic stress resistance, abnormal mitochondrial and nucleolar morphology, and increased transposable element transposition. Related genes in other species are linked to toxin resistance.