PAB1 — Fusarium oxysporum Fo47

Summary

FoPAB1 (FOZG_00640) on chromosome JH717896 of Fusarium oxysporum Fo47 encodes a protein containing WD40 repeats and a PP2A_PR55 domain, and is annotated with protein phosphatase activator and regulator activities. The gene is associated with multiple cell cycle processes, including regulation of mitotic entry, the G2/M transition checkpoint, spindle assembly checkpoint, and exit from mitosis, as well as achiasmate meiosis I, homologous chromosome segregation, and microautophagy. It is linked to hyperosmotic salinity response, positive regulation of transcription by transcription factor localization, and upregulation of protein localization in membranes. Phenotypic associations include absent sporulation efficiency, decreased septum formation, increased thermotolerance, increased polyploidy rate, delayed carbon source utilization, abnormal pheromone production, and decreased flocculation and intracellular transport. The protein localizes to the PP2A complex, mitotic spindle, spindle pole body, bud tip and neck, nucleus, cytosol, and fungal-type vacuole membrane.