BIP — Nicotiana attenuata

Summary

A4A49_23212 (BIP) on coyote tobacco chromosome 8 encodes a member of the Hsp70 family, a chaperone with ATP hydrolase activity that binds ATP and heat shock proteins, and is annotated as a protein folding chaperone. It is associated with the unfolded protein response, protein refolding in the endoplasmic reticulum, the ERAD pathway, and the ER-specific unfolded protein response. The gene is linked to leaf senescence, including its negative regulation, as well as pollen germination and tube growth, cell death, jasmonic acid signaling, secretion, response to virus, protein breakdown, and nitric oxide storage. It is localized to the ER lumen, chaperone complex, tonoplast, membrane, cytoplasm, and nucleus. Related genes in other species link the family to similar chaperone functions. The gene is also associated with transpiration rate and stomatal resistance.