ATR2 — Nicotiana attenuata

Summary

ATR2 (MYC2) on coyote tobacco chromosome scaffold00814 encodes a bHLH transcription factor of the AIB/MYC-like family, with annotated RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription corepressor and coactivator activities, and associations with histidine phosphotransfer kinase, MAPKK, SUMO transferase, and histone binding activities. In this species, MYC2 is linked to nicotine and phenolamide biosynthesis, superoxide metabolism, induced systemic resistance via ethylene signaling, regulation of defense response to insects, glucosinolate biosynthetic process regulation, trichome spacing, proline metabolism, and ascorbate biosynthesis regulation. It is associated with herbivore resistance, glandular trichome development, aluminum tolerance, and caffeoylputrescine accumulation. The gene is connected to JAZ/MYC-mediated jasmonate signaling pathways and localizes to the nucleus, mediator complex, plasmodesmata, and Golgi. Studies in related genes in other species link the MYC2 family to chilling tolerance, drought tolerance, seed maturation, fruit quality, and pathogen resistance.