SHD — Nicotiana attenuata

Summary

A4A49_19421 (symbol SHD, NaSHD) on Nicotiana attenuata chromosome 12 encodes a heat shock protein 90 family member containing Hsp90 and HATPase_C domains, with ATP-dependent protein folding chaperone activity and numerous additional annotated molecular functions including DNA polymerase, transcription regulator, and pectate lyase activities. The gene is associated with diverse biological processes such as viral translation, cellular response to unfolded protein, double-strand break repair, and respiratory burst involved in defense response. It localizes to the chloroplast outer membrane, ER lumen, and Tic complex. Associations include floral organ morphology, seed set percent, bacterial and viral disease response, submergence tolerance, temperature stress response, aphid response, and reproductive growth time. Studies of related genes in other species link the family to thermotolerance, broad-spectrum disease resistance, salinity tolerance, and chloroplast envelope maintenance.