CAD — Nicotiana attenuata

Summary

A4A49_19827 (CAD) in coyote tobacco (Nicotiana attenuata, scaffold01313) encodes a CAD-like protein with oxidoreductase activity acting on CH-OH groups using NAD or NADP as acceptor, and exhibits geraniol dehydrogenase, vomilenine reductase, mannitol dehydrogenase, 8-hydroxygeraniol dehydrogenase, and cinnamyl-alcohol dehydrogenase activities, along with zinc binding. The gene is associated with oviposition, glycan biosynthesis, primary metabolism, pigmentation, phenylpropanoid metabolism, photorespiration, detoxification, lignin anabolism, flavonoid anabolism, alkaloid metabolism, and carbohydrate metabolism. It is linked to starch mobilization and lignin content. The encoded protein localizes to the cytoplasm. Studies of related genes in other species connect the family to alcohol dehydrogenase (ADH9, ELI3, MTD, GEDH1, VR, RR6, 10HGO) and EC numbers 1.1.1.183, 1.5.1.32, 1.1.1.324, 1.1.1.255, 1.1.1.195, and 1.3.1.-.