NHX1 — Nicotiana attenuata

Summary

A4A49_20518 (NHX1/NHX4) on coyote tobacco chromosome 8 encodes a sodium/hydrogen exchanger belonging to the CPA1 cation/H⁺ exchanger family, with annotated lithium:proton and potassium:proton antiporter activities, sodium transporter activity, NAD ADP-ribosyltransferase activity, protein kinase activity and protein binding. The gene is associated with vacuolar membrane transport, sodium import, lithium export, cell pH regulation, potassium ion homeostasis, response to superoxide, and nitric oxide anabolism. It localises to the tonoplast, vacuole, endosome, retromer complex, MVB, chloroplast envelope and plastid. Associations include leaf potassium content, sodium uptake, yield, photosynthetic rate, stomatal resistance, plant height, root development, transpiration rate, UV-B light sensitivity, jasmonic acid and abscisic acid sensitivity, disease tolerance, and high temperature stress response. Related genes in other species link the family to vacuolar pH homeostasis, potassium accumulation, seed germination, heat and cold tolerance, and biomass production.