M2 — Nicotiana attenuata

Summary

A4A49_20955 (M2, CYP) on coyote tobacco chromosome scaffold02197 encodes a cyclophilin-type peptidylprolyl isomerase (PPIase) with cis-trans proline isomerase activity, and is also annotated with peroxidase activity, salicylic acid binding, and L-serine O-acetyltransferase activity. The gene is associated with nicotine metabolism, protein proline isomerization, the methylerythritol phosphate (MEP) pathway, and responses to chlorate and sulfate starvation. It has been linked to numerous traits including variegated leaf, leaf length, starch grain synthesis, sucrose content, jasmonic acid content, photosynthetic rate, respiration rate, root hair length, herbicide sensitivity, and temperature stress response. Associations also include heat stress tolerance, pathogen defense, disease resistance, pre-mRNA splicing, auxin transport, gravitropism, and embryo patterning. Related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, phototropism, and drought response.