MLO — Nicotiana attenuata

Summary

A4A49_20459, designated MLO8 on chromosome 2 of coyote tobacco (Nicotiana attenuata), encodes a calmodulin-binding protein. This gene is associated with regulation of secondary metabolite biosynthesis, including nicotine and alkaloid anabolism, as well as salicylic acid anabolism and the metabolic burst. It is linked to pollen tube reception and guidance, auxin transport, response to hormones and stress, and protein localization to the plasma membrane. The encoded protein localizes to the endomembrane system, plasma membrane, cytoplasm, nucleus, and mitochondria. Associations with shoot dry weight and drought tolerance have also been noted. Studies of related MLO family members in other species connect this gene family to powdery mildew resistance and pollen tube guidance defects.