M2 — Nicotiana attenuata

Summary

A4A49_19947 (NaM2) on chromosome 2 of coyote tobacco encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with additional domains including a tetratricopeptide repeat (TPR)-like helical domain. The gene product is associated with diverse molecular functions such as L-serine O-acetyltransferase activity, peroxidase activity, salicylic acid binding, and histone binding. It is linked to biological processes including nicotine metabolism, cysteine anabolism, protein proline isomerization, and the methylerythritol phosphate (MEP) pathway. Localization evidence connects it to the Golgi stack, thylakoid lumen, and secretory vesicles. The gene has been associated with leaf length, photosynthetic rate, starch grain synthesis, jasmonic acid content, sucrose content, and responses to temperature stress, light intensity, and herbicides. Related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, and phototropism.