AXR6 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0615160 (symbol AXR6, also known as CUL4 and HvCUL3C) on barley chromosome 6H encodes a cullin family protein with ubiquitin ligase complex scaffold activity, NEDD8 transferase activity, and auxin receptor activity. In barley, the gene is associated with grain morphology. Annotated associations link it to regulation of ethylene biosynthesis, protein neddylation, response to organophosphorus, and post-embryonic root development. The encoded protein localises to the CRL complex, COP9 signalosome, and nucleotide-excision repair complex. The gene is further connected to diverse traits including Cercospora leaf spot response, rice narrow brown leaf spot disease response, wheat common root rot response, fruit ripening, photoperiod sensitivity, bacterial blight disease resistance, and endosperm morphology. Studies of related genes in other species link the family to auxin response, lesion mimic, drought stress, and disease resistance.