IRT1 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.4HG0333700 (HvIRT1) on barley chromosome 4H encodes a ZIP family metal transporter with transmembrane transporter activity for copper, zinc, manganese, iron, and cadmium ions, as well as phosphoinositide and ubiquitin binding. HvIRT1 is associated with metal ion transport, cellular and multicellular iron homeostasis, nickel and cadmium transport, stress responses to zinc and hypoxia, response to bacteria, regulation of abscisic acid signaling, and endosome membrane budding. It localizes to the plasma membrane, endosomes, late endosome membrane, TGN, ESCRT I complex, nucleus, and extracellular space. The gene is linked to traits including zinc concentration, grain filling period, and plant growth, and to phenotypes such as iron and metal homeostasis, iron deficiency tolerance, cadmium accumulation and tolerance, chlorophyll content, photosynthetic efficiency, disease resistance, root and leaf development, and chloroplast development.