lip1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_22198 (symbol lip1) in Fusarium oxysporum f. sp. lycopersici 4287 encodes a carboxylesterase with a carboxylesterase B domain and an alpha/beta hydrolase fold, and is annotated with carboxylesterase and triacylglycerol lipase activity. The gene is associated with lipolysis, lipid metabolism, cholesterol metabolism, and secretion, and its product is predicted to localise extracellularly. Studies of related carboxylesterase/lipase family members in other fungi link the family to triacylglycerol lipase activity (EC 3.1.1.3) and carboxylesterase activity (EC 3.1.1.1), and have been associated with unaffected pathogenicity in some contexts. The gene has also been linked through sequence similarity to related genes in other species, including plant-pathogenic fungi such as Verticillium dahliae and various Fusarium formae speciales, as well as to hosts including tomato and carnation.