fol3 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_05023 (fol3) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with folylpolyglutamate synthase and dihydrofolate synthase activities, belonging to the Mur ligase C-terminal domain superfamily and the folylpolyglutamate synthase family. The gene product is associated with tetrahydrofolate polyglutamylation, folate and derivative biosynthesis, glutamate metabolism, and one-carbon metabolism. It localises to the mitochondrial lumen, mitochondrial inner membrane, mitochondria, cytoplasm, cytosol, and nucleus. The gene is associated with fruit size. Studies of related genes in other species link the family to EC 6.3.2.12 (dihydrofolate synthase) and EC 6.3.2.17 (folylpolyglutamate synthase) activities.