MBF1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoMBF1 (FOXG_05229) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a multiprotein bridging factor 1 (MBF1) family protein containing an MBF1_N domain and a Cro/C1-type helix-turn-helix domain. The product is associated with DNA binding, ribosome binding, maintenance of translational fidelity, GCN2-mediated signaling, rescue of stalled cytosolic ribosomes, and DNA-dependent transcription. It localises to the cytoplasm, nucleus, and extracellular space. The gene is linked to numerous phenotypes including increased pheromone sensitivity and mating response, decreased pseudohyphal growth, altered autophagy, reduced gamma ray resistance, increased hyperosmotic stress resistance, decreased acquired thermotolerance, increased chitin deposition, increased telomere length, decreased sporulation, and abnormal cell shape, colony appearance, and endoplasmic reticulum morphology. Related genes in other species are associated with reduced virulence and heat sensitivity.