HOT1 — Arabidopsis thaliana

Summary

AT1G74310 (HOT1, AtHSP101) encodes a member of the ClpB/Hsp100 family of AAA+ ATPases with ATP-dependent peptidase activity. In Arabidopsis thaliana, this gene is associated with heat stress tolerance and tobamovirus infection resistance. It has been linked to numerous traits including biomass yield, photosynthetic ability, photoperiod-sensitive flowering time, fruit yield, leaf morphology, root phototropism, and responses to light quality, UV-B, glyphosate, manganese, and gibberellic acid. The encoded protein is associated with chloroplast and thylakoid membranes, the Tic complex, and nuclear bodies, and has been connected to processes including protein unfolding, chloroplast development, chlorophyll biosynthesis, circadian calcium oscillation, and hydrogen peroxide signaling. Studies of related genes in other species link the family to thermotolerance, chloroplast homeostasis, and stress acclimation.