ICS1 — Arabidopsis thaliana

Summary

AT1G74710, known as ICS1, SID2, or EDS16 in Arabidopsis thaliana on chromosome 1, encodes an isochorismate synthase with isochorismate mutase activity (EC 5.4.4.2), localizing to the plastid. This gene is associated with salicylic acid accumulation and biosynthesis, as well as basal defense, non-host resistance to pathogens like Pseudomonas syringae, and systemic acquired resistance. It is linked to stress responses, including tolerance to heat, drought, cold, ozone, cadmium, and salt, and to traits such as hybrid seed viability, root development, leaf senescence, and flowering time. Associations also extend to phylloquinone anabolism, photosynthesis regulation, and agronomic traits like harvest index, seed yield, nitrogen content, and stomatal resistance. Studies of related genes in other species connect the family to seedling vigor, lycopene content, and net photosynthetic rate.