NR1 — Arabidopsis thaliana

Summary

AT1G77760 (NR1/NIA1) in Arabidopsis thaliana encodes a nitrate reductase (EC 1.7.1.1) with NADH:nitrate reductase activity, also annotated for cytokinin riboside 5'-monophosphate phosphoribohydrolase activity, molybdenum cofactor and heme binding, and SUMO transferase activity. The gene is associated with nitrate reduction, nitric oxide generation and metabolism, nitrogen homeostasis, and regulation of nitrate assimilation. Observed phenotypes link NR1 to lateral root development, gravitropic response, biomass accumulation, and virus resistance. It has been connected to traits including nitrate content, nitrogen sensitivity, seed protein content, germination ratio, root branching, and responses to copper, aluminum, and phosphorus. Additional associations include freezing tolerance, stomatal function, flowering time, disease susceptibility, and rhizosphere microbiome composition. Studies of related genes in other species connect the family to leaf nitrogen content, grain size, photosynthetic capacity, and root development traits.