ASK1 — Arabidopsis thaliana

Summary

AT1G75950 (ASK1, also known as SKP1A or UIP1) in Arabidopsis thaliana encodes a SKP1-like protein containing the Skp1 component dimerisation domain. The gene product is associated with ubiquitin-protein transferase activity and localises to nuclear ubiquitin ligase complexes and the proteasome core. ASK1 has been linked to diverse biological processes including male germ cell proliferation, meiosis I, meiotic DNA double-strand break formation, and regulation of gibberellic acid-mediated signalling. It is associated with strigolactone-mediated axillary bud dormancy and tillering suppression pathways, and has been associated with traits such as tiller bud dormancy, grain size, inflorescence height, seedling vigour, and responses to drought, heat, cold, and parasitic weeds. Studies of related genes in other species link the family to spikelet number, heterosis, and disease tolerance.