TN2 — Phaseolus vulgaris

Summary

PvTN2 (PHAVU_011G181366) on French bean chromosome 11 encodes a TIR-NBS-LRR class disease resistance protein with domains including NB-ARC, leucine-rich repeats, and a Toll/interleukin-1 receptor domain. The protein exhibits ATP hydrolase activity, DNA binding transcription factor activity, and phosphoinositide binding. PvTN2 is associated with defense responses, including callose deposition, systemic acquired resistance via salicylic acid signaling, and positive regulation of the hypersensitive response. It is linked to responses to UV, ozone, hypoxia, singlet oxygen, insects, and viruses, as well as regulation of stomatal closure, hydrogen peroxide metabolism, and programmed cell death. The gene is associated with traits such as biomass yield, seed yield, water use efficiency, disease tolerance, and responses to abiotic stresses including low temperature and oxidative stress. Studies of related genes in other species link the family to bacterial wilt resistance, chilling tolerance, and aluminum tolerance.