TN2 — Phaseolus vulgaris

Summary

PvTN2 (PHAVU_L002637) in French bean encodes a protein with domains including NB-ARC, leucine-rich repeats, and a Toll/interleukin-1 receptor domain. The product exhibits ATP hydrolase, NADP nucleosidase, and DNA-binding transcription factor activities, and is associated with phosphatidylinositol-4,5-bisphosphate binding. PvTN2 is associated with defense responses against bacteria, viruses, and insects, as well as systemic acquired resistance via salicylic acid signaling, regulation of programmed cell death and the hypersensitive response, and responses to UV, ozone, hypoxia, and singlet oxygen. It is linked to traits including seed yield, biomass, water use efficiency, anthocyanin content, root thickness, and tolerance to biotic and abiotic stresses such as bacterial wilt, chilling, aluminum, and salt. Studies of related genes in other species link the family to resistance against Pseudomonas syringae, Leptosphaeria maculans, and root-knot nematode.