TN2 — Phaseolus vulgaris

Summary

PHAVU_011G195800, designated PvTN2 on French bean chromosome 11, encodes a protein with domains including NB-ARC, TIR, and leucine-rich repeats, and exhibits ATP hydrolase, NADP nucleosidase, and DNA-binding transcription factor activities. The gene is associated with defense responses to Gram-negative bacteria, viruses, and insects, as well as systemic acquired resistance via salicylic acid signaling, positive regulation of the hypersensitive response, and programmed cell death. It is linked to regulation of stomatal closure, hydrogen peroxide metabolism, and responses to UV, ozone, hypoxia, and singlet oxygen. Associations with agronomic traits include biomass yield, seed yield, water use efficiency, disease tolerance, oxidative stress response, low temperature stress response, anthocyanin content, root thickness, and leaf chlorosis. Studies of related genes in other species connect the family to bacterial wilt resistance, chilling tolerance, aluminum tolerance, and resistance to fungal pathogens such as Botrytis cinerea and Leptosphaeria maculans.