M2 — Nicotiana attenuata

Summary

A4A49_58536, designated NaM2 on chromosome 12 of coyote tobacco (Nicotiana attenuata), encodes a cyclophilin-type peptidylprolyl isomerase (PPIase) with cis-trans proline isomerase activity and additional annotated molecular functions including L-serine O-acetyltransferase activity, peroxidase activity, and binding of salicylic acid, cyclosporin A, histones, and chromatin. The gene is associated with nicotine metabolism, cysteine anabolism, the MEP pathway, protein proline isomerization, and alternative mRNA splicing. It has been linked to diverse traits including leaf length, starch grain synthesis, variegated leaf, photosynthetic rate, respiration rate, sucrose and jasmonic acid content, chloroplast development, temperature stress response, herbicide sensitivity, zinc sensitivity, root hair length, and root mass density. Localization evidence connects the product to the thylakoid lumen, Golgi stack, secretory vesicle, and proteasome. Related genes in other species are linked to drought response, cold stress tolerance, hydrotropism, phototropism, embryo patterning, and sulfate assimilation.