QPT — Nicotiana attenuata

Summary

A4A49_58606 (QPT, NaQPT) on chromosome 12 of coyote tobacco (Nicotiana attenuata) encodes a nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19), a member of the NadC/ModD family. The encoded protein is associated with quinolinate breakdown, nicotine metabolism and anabolism, NAD anabolism, secondary metabolism, and alkaloid metabolism. It is linked to responses to jasmonic acid, wounding, and abscisic acid, as well as regulation of gene expression, sumoylation, and embryo development. The product localizes to mitochondria, cytosol, and nucleus. Associations with traits include heterosis, respiration rate, starch content, stomatal opening, chlorophyll content, abscisic acid sensitivity, and flowering time. Phenotypic connections include nicotine biosynthesis, protein stability, heat stress response, basal immunity, viral resistance, defense gene expression, and plant defense. Studies of related genes in other species link the family to embryo viability.