RDR6 — Nicotiana attenuata

Summary

A4A49_18155 (RDR6) in Nicotiana attenuata encodes an RNA-dependent RNA polymerase (EC 2.7.7.48) with RNA-directed RNA polymerase activity, RNA binding, and ubiquitin ligase binding. It is associated with posttranscriptional gene silencing, siRNA and ta-siRNA processing, RNA-dependent gene silencing, antiviral response, systemic acquired resistance, heat acclimation, and hypersensitivity. The gene is linked to vegetative phase change, maintenance of shoot apical meristem identity, carpel and pistil development, pollen recognition, wax anabolism, and homeostasis. It localizes to the RNA-dependent RNA polymerase complex, stress granules, endoplasmic reticulum, mitochondria, cytoplasm, and nucleus. Associations include leaf number, shape, and morphology, anthocyanin content, viral disease response, and abiotic stress response traits. Studies of related genes in other species link the family to virus resistance, disease tolerance, leaf curling, and chlorophyll content.