M2 — Lactuca sativa

Summary

LsM2, on lettuce chromosome 8, encodes a protein with a cyclophilin-type PPIase domain. The gene product is associated with cis-trans proline isomerase activity, cyclosporin A binding, salicylic acid binding, and peroxidase activity, and is linked to processes including sesquiterpenoid metabolism, lactone anabolism, protein proline isomerization, and alternative mRNA splicing. Associations with traits such as variegated leaf, heterosis, starch grain synthesis, respiration rate, temperature stress response trait, photosynthetic rate, sucrose content, and herbicide sensitivity have been noted. The gene is also connected to phenotypes including heat stress tolerance, pre-mRNA splicing, seedling growth, pathogen defense response, root hydrotropism, and auxin transport. Studies of related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, and embryo patterning.