M2 — Lactuca sativa

Summary

LsM2, a cyclophilin-type peptidyl-prolyl cis-trans isomerase on lettuce chromosome 8, encodes a protein with cis-trans proline isomerase activity and additional annotated molecular functions including salicylic acid binding, peroxidase activity, and histone binding. The gene is associated with sesquiterpenoid metabolism, lactone biosynthesis, protein proline isomerization, and regulation of ARF protein signal transduction. It has been linked to numerous traits including variegated leaf, heterosis, photosynthetic rate, respiration rate, temperature stress response, sucrose content, jasmonic acid content, herbicide sensitivity, root hair length, and chloroplast development. Localization evidence connects the product to the Golgi stack, thylakoid lumen, secretory vesicle, and proteasome. Studies of related genes in other species associate the family with heat stress tolerance, pre-mRNA splicing, pathogen defense, drought response, cold stress tolerance, hydrotropism, and embryo patterning.