SHD — Lactuca sativa

Summary

LsSHD, on chromosome 8 of garden lettuce (Lactuca sativa), encodes a heat shock protein 90 (Hsp90) family member, containing Hsp90 and HATPase domains. The product is annotated with ATP-dependent protein folding chaperone activity and numerous other molecular functions including DNA polymerase, transcription regulator, and telomeric repeat binding activities. LsSHD is associated with diverse biological processes such as cellular response to unfolded protein, brassinosteroid stimulus, and heat stress, as well as base-excision repair, double-strand break repair, and circadian clock photoentrainment. It is linked to traits including floral organ morphology, seed set percent, bacterial and viral disease responses, submergence tolerance, temperature stress response, aphid response, photoperiod-sensitive flowering time, and seed viability. Studies of related genes in other species connect the family to thermotolerance, broad-spectrum disease resistance, salinity tolerance, and developmental regulation.