HMG1 — Lactuca sativa

Summary

LsHMG1 (HMG1) on chromosome 8 of garden lettuce encodes a hydroxymethylglutaryl-CoA reductase (HMGR). This gene is associated with the MVA pathway, isoprenoid, sterol, triterpenoid, saponin, and terpenoid anabolism, as well as coenzyme A and pyruvate metabolism. It is linked to responses to jasmonic acid and absence of light, and to protein binding. The encoded protein localizes to multiple membranes, including the endoplasmic reticulum, plastid, chloroplast, mitochondrial, and peroxisome membranes. LsHMG1 is associated with photosynthetic rate, plant height, biomass, flowering time, male fertility, seed phytosterol content, and defense and wound responses. Related genes in other species link the family to isoprenoid biosynthesis, phytosterol content, disease resistance, and fruit development.