M2 — Lactuca sativa

Summary

LsM2, located on chromosome 8 of garden lettuce (Lactuca sativa), encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with a cyclophilin-like domain, and is annotated with multiple molecular functions including cyclosporin A binding, salicylic acid binding, peroxidase activity, and U5/U2 snRNA binding. The gene is associated with a wide range of biological processes, including sesquiterpenoid metabolism, lactone anabolism, protein proline isomerization, sporopollenin biosynthesis, and response to chlorate. It has been linked to numerous traits such as variegated leaf, heterosis, starch grain synthesis, respiration rate, temperature stress response, zinc sensitivity, phototropism, sucrose content, herbicide sensitivity, and photosynthetic rate. Additionally, LsM2 is connected to phenotypes including heat stress tolerance, pre-mRNA splicing, seedling growth, pathogen defense, and root hydrotropism. Studies of related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, and phototropism.