SHD — Lactuca sativa

Summary

LsSHD, on chromosome 8 of garden lettuce, encodes a heat shock protein 90 (HSP90) family member, characterized by Hsp90_N, HSP90_C and HATPase_C domains and annotated with ATP-dependent protein folding chaperone activity. The gene is associated with a wide range of biological processes including cellular response to unfolded protein, cellular thermotolerance, inhibition of the cellular response to heat stress, response to brassinosteroid stimulus, and double-strand break repair. It is linked to numerous agronomic traits such as seed set percent, submergence tolerance, bacterial and viral disease response, aphid response, photoperiod-sensitive flowering time, temperature stress response, and floral organ morphology. Localization evidence connects the product to the chloroplast outer membrane, ER lumen, and cell periphery. Studies of related genes in other species link the HSP90 family to thermotolerance, broad-spectrum disease resistance, salinity tolerance, and developmental regulation.