M2 — Lactuca sativa

Summary

LsM2 (M2) on chromosome 8 of garden lettuce encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase, possessing cyclosporin A binding, peroxidase activity, and additional annotated molecular functions including GTP:GDP antiporter activity and U5/U2 snRNA binding. The gene is associated with diverse biological processes such as sesquiterpenoid metabolism, lactone biosynthesis, protein proline isomerization, chaperone-mediated protein complex assembly, and alternative mRNA splicing. It is linked to numerous traits including variegated leaf, heterosis, photosynthetic rate, respiration rate, sucrose content, herbicide sensitivity, root hair length, chloroplast development, and responses to temperature stress, light intensity, and zinc. Associations also extend to phenotypes such as heat stress tolerance, pre-mRNA splicing, pathogen defense, root hydrotropism, and auxin transport. Related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, and embryo patterning.