M2 — Lactuca sativa

Summary

LsM2, on lettuce chromosome 7, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with a cyclophilin-like domain, and is annotated with additional molecular functions including GTP:GDP antiporter activity, U5 and U2 snRNA binding, L-serine O-acetyltransferase activity, cyclosporin A binding, salicylic acid binding, peroxidase activity, histone and chromatin binding, and protein dimerization activity. The gene is associated with sesquiterpenoid metabolism, lactone biosynthesis, protein proline isomerization, regulation of ARF protein signal transduction, sporopollenin biosynthesis, alternative mRNA splicing, and responses to chlorate and sulfate starvation. It has been linked to traits including variegated leaf, heterosis, starch grain synthesis, respiration rate, temperature stress response, zinc sensitivity, phototropism, sucrose content, herbicide sensitivity, inflorescence and cotyledon morphology, root hair length, chloroplast development, jasmonic acid content, photosynthetic rate, and stomatal closure time. Related genes in other species connect the family to water stress tolerance, cold stress response, hydrotropism, phototropism, embryo patterning, and cell polarity.