HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C700365000 on lettuce chromosome 7, is a P-type ATPase with heavy-metal-associated domains, annotated with copper, zinc, cadmium, potassium, and sodium transporter activities. In lettuce, it is associated with detoxification of zinc, copper, and cadmium ions, copper and iron ion membrane transport, cellular copper and zinc homeostasis, proton export, cell pH regulation, and response to cobalt and toxic substances. It is linked to traits including copper sensitivity, drought tolerance, disease tolerance, high temperature stress response, oxidative stress response, leaf morphology and senescence, root development and length, plant height, flowering time, germination rate, nitrate uptake, and stomatal opening and closure. Related genes in other species connect the family to copper transport, photosensitivity under high light, the water-water cycle of photosynthesis, and cadmium and zinc translocation and detoxification.