M2 — Lactuca sativa

Summary

LsM2, on lettuce chromosome 7, encodes a protein with cyclophilin-type PPIase and TPR domains, and is annotated with diverse molecular functions including cyclosporin A binding, salicylic acid binding, histone binding, and peroxidase activity. The gene is associated with sesquiterpenoid metabolism, lactone anabolism, protein proline isomerization, and alternative mRNA splicing via the spliceosome. It has been linked to numerous agronomic traits including variegated leaf, heterosis, starch grain synthesis, respiration rate, photosynthetic rate, sucrose content, root hair length, chloroplast development, jasmonic acid content, and responses to temperature stress, light intensity, and herbicides. Studies of related genes in other species connect the family to heat stress tolerance, pre-mRNA splicing, hydrotropism, phototropism, drought response, and resistance to Botrytis cinerea.