HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C700366050 on chromosome 7 of garden lettuce (Lactuca sativa), is a member of the P-type ATPase family, specifically a heavy-metal-associated (HMA) domain-containing protein with annotated copper and zinc transporter activities. The gene is associated with detoxification of copper, zinc, and cadmium ions, as well as copper and zinc ion homeostasis and transport. It has been linked to a wide range of traits including copper sensitivity, drought tolerance, high temperature stress response, oxidative stress response, bacterial disease response, leaf morphology, root development, plant height, flowering time, and germination rate. Localization evidence connects the product to the vacuolar membrane, chloroplast thylakoid membrane, and chloroplast envelope. Studies of related genes in other species link the family to copper transport, photosynthesis under high light, and heavy metal tolerance.