HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C700364990 on lettuce chromosome 7, is a P-type ATPase of the IB subfamily, annotated with copper, zinc, and cadmium transporter activities. It is associated with detoxification of zinc, copper, and cadmium ions, copper ion homeostasis and membrane transport, response to cobalt ion, cell pH regulation, and regulation of root morphogenesis. The gene has been linked to traits including copper sensitivity, drought tolerance, high temperature stress response, oxidative stress response, bacterial disease response, leaf morphology, root length, plant height, flowering time, germination rate, and leaf senescence. Studies of related genes in other species connect the family to chloroplast copper delivery, photosensitivity under high light, the water-water cycle of photosynthesis, cadmium translocation, and zinc homeostasis.