PMIT1 — Lactuca sativa

Summary

LsPMIT1, located on chromosome 1 of garden lettuce (Lactuca sativa), encodes a member of the NRAMP family of metal ion transporters. The gene product exhibits transmembrane transporter activity for manganese, iron, and cadmium ions. LsPMIT1 is associated with manganese ion homeostasis and transport, including responses to manganese starvation, as well as iron and cadmium ion membrane transport, and positive regulation of reactive oxygen species metabolism. It is linked to vacuolar, endosome, and trans-Golgi network membrane localisation. The gene has been connected to photosynthetic rate, root length, and plant height, and to phenotypes including growth under manganese deficiency, copper homeostasis, cadmium transport, iron remobilization, manganese uptake and translocation, seed germination, and photosystem II activity. Studies of related genes in other species link the NRAMP family to iron reutilization, manganese homeostasis, pathogen resistance, and cadmium tolerance.