LOX — Lactuca sativa

Summary

LsLOX, encoded by the gene LSAT_V11C100022180 on lettuce chromosome 1, is a lipoxygenase family protein containing the conserved LipOase and PLAT/LH2 domains. The enzyme exhibits linoleate 13S-lipoxygenase and phytoene dehydrogenase activities, acting as an oxidoreductase that incorporates molecular oxygen. In lettuce, LsLOX is associated with oxylipin and green leaf volatile biosynthesis, lipid oxidation, and responses to jasmonic acid, salicylate, wounding, and other organisms. It is also linked to isoprenoid, terpenoid, and fatty acid anabolism, as well as triglyceride metabolism and translation elongation. The protein localizes to the chloroplast thylakoid and stroma. Additionally, LsLOX has been connected to nitrate content and transport. Studies of related genes in other species further link the family to linoleate 13S-lipoxygenase activity (EC 1.13.11.12).