brlA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_20849 (symbol brlA) on chromosome 3 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a C2H2-type zinc-finger transcription factor with sequence-specific DNA-binding activity, including RNA polymerase II cis-regulatory region binding and zinc binding. The gene is associated with sporulation, conidia formation, spore formation, and sporocarp development involved in sexual reproduction. It is also linked to regulation of secondary metabolite biosynthesis and negative regulation of transcription by RNA polymerase II. The encoded protein localises to the nucleus, membrane, and the Ste12p-Dig1p-Dig2p and Tec1p-Ste12p-Dig1p complexes. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.