SHD — Arabidopsis thaliana

Summary

AT4G24190 (SHD, also known as SHEPHERD or HSP90.7) encodes a member of the heat shock protein 90 family, characterized by Hsp90 and HATPase domains, and annotated as an ATP-dependent protein folding chaperone. In Arabidopsis, SHD is associated with stem cell development, thermomorphogenesis, macroautophagy, and the cellular response to unfolded proteins, as well as with mitochondrial and endoplasmic reticulum function, drought tolerance, and abiotic stress responses. The gene has been linked to diverse traits including floral organ morphology, seed set, bacterial and viral disease responses, submergence tolerance, temperature stress tolerance, and plant immunity. It localizes to the ER lumen, chloroplast membranes, and the cell periphery, and is connected to sterol biosynthesis and secondary metabolism. Studies of related genes in other species link the family to disease resistance and heavy metal tolerance.