NBR1 — Arabidopsis thaliana

Summary

AT4G24690, known as NBR1 (next to BRCA1 gene 1), encodes a protein with ubiquitin-binding activity, Atg8-specific protease activity, and chaperone protein binding, containing PB1, UBA, and zinc-finger domains. In Arabidopsis thaliana, NBR1 is associated with autophagy, including selective autophagy, aggrephagy, and xenophagy, as well as abscisic acid signaling, stomatal closure, seed germination, lateral root initiation, antiviral resistance, and heat stress resistance. The protein localizes to the phagophore, vacuole, cytoplasm, nucleus, and mitochondria. Associations with traits include seed yield, leaf senescence, submergence tolerance, oxidative stress response, and sulfonylurea herbicide sensitivity. Related genes in other species are linked to bacterial resistance.