FWA — Arabidopsis thaliana

Summary

AT4G25530, known as FWA or FLOWERING WAGENINGEN, encodes a homeodomain-containing transcription factor belonging to the HD-Zip IV family, featuring a START domain and homeobox-like superfamily structure. It is annotated with DNA-binding transcription factor activity, histone methylase activities (H3K4 and H3K36), and lipid, SUMO, and phosphatidylethanolamine binding. FWA is associated with diverse biological processes including transposable element silencing, DNA imprinting, maintenance of floral organ identity, epidermal cell differentiation, anthocyanin accumulation in response to UV light, carotenoid and folate metabolism, cutin biosynthesis, and iron-sulfur cluster assembly. It localizes to the nucleus, cytoplasm, and plasmalemma. The gene is linked to numerous agronomic traits such as flowering time, photoperiod sensitivity, fruit number, harvest index, biomass yield, drought recovery, leaf area, stem length, and sucrose content, as well as phenotypes including late flowering, genomic imprinting, and cuticle development.