CYP51 — Sorghum bicolor

Summary

SORBI_3005G161700, designated CYP51 on sorghum chromosome 5, encodes a cytochrome P450 monooxygenase with sterol 14-demethylase activity, also annotated as a taxoid 7beta-hydroxylase and abscisic acid 8'-hydroxylase. The gene is associated with sterol metabolism and biosynthesis, abscisic acid breakdown, indole alkaloid and saponin anabolism, and response to jasmonic acid. Its product localises to the endoplasmic reticulum membrane and other intracellular membranes. Associations with secondary metabolism and sterol biosynthesis pathways link CYP51 to plant growth regulation and stress signalling. Studies of related genes in other species connect the family to taxoid hydroxylation and abscisic acid catabolism, though these functions are not yet established in sorghum.