CYP51 — Sorghum bicolor

Summary

SORBI_3005G162000, designated CYP51 on sorghum chromosome 5, encodes a cytochrome P450 sterol 14-demethylase (EC 1.14.14.154) with monooxygenase, heme-binding and iron-binding activities, and belongs to the CYP450 sterol 14-demethylase family. The gene is associated with sterol biosynthesis and metabolism, including demethylation and sterol anabolism, as well as secondary metabolism pathways. It has been linked to responses to UV-C, jasmonic acid, salicylate, and insect defense, along with terpenoid, saponin, indole alkaloid, and alkaloid anabolism. The product localizes to the endoplasmic reticulum membrane and membrane compartments. Studies of related genes in other species connect the family to additional monooxygenase activities (EC 1.14.14.53, 1.14.14.103, 1.14.14.51).