CYP51 — Sorghum bicolor

Summary

SORBI_3005G162300, designated CYP51 on sorghum chromosome 5, encodes a cytochrome P450 family protein belonging to the sterol 14-demethylase subfamily (CYP450_sterol_14alpha_dmase). The enzyme exhibits sterol 14-demethylase activity (EC 1.14.14.154), along with tabersonine 16-hydroxylase and abscisic acid 8'-hydroxylase activities, and is localized to the endoplasmic reticulum membrane. This gene is associated with sterol biosynthesis and metabolism, abscisic acid breakdown and response, demethylation, and the biosynthesis of indole alkaloids, saponins, and phenylethylamine. It is also linked to fruit ripening, digestion, and response to thirst. Related genes in other species link the family to additional oxidoreductase activities, though these associations are not yet established in sorghum.