CYP51 — Sorghum bicolor

Summary

SORBI_3005G161900 (CYP51) on sorghum chromosome 5 encodes obtusifoliol 14-alpha demethylase, a cytochrome P450 enzyme with sterol 14-demethylase activity that also exhibits monooxygenase and oxidoreductase functions. The gene is associated with sterol, brassinosteroid, terpenoid, saponin, flavone, and indole alkaloid biosynthesis, as well as demethylation, cholesterol metabolism, and steroidogenesis. It has been linked to defense responses against insects, response to UV-C, pollen tube development, skotomorphogenesis, microtubule bundling, and digestion. The encoded protein localizes to the endoplasmic reticulum membrane. Studies of related genes in other species connect the CYP51 family to additional cytochrome P450 activities including ent-kaurenoic acid monooxygenase and flavonoid 3'-monooxygenase functions.